ABSTRACT
Despite the wide spread use of gastric antisecretory agents and eradication therapy, the incidence of perforation of duodenal ulcer remains more or less the same [5 10%]. There are certain well-defined risk factors that indicate, an increased liability to develop the disease The association of various probable risk factors such as H. Pylon, inadequate dietary intake, smoking, alcohol, ABO blood group and non-steroidal anti-inflammatory drugs has been studied. To evaluate the probable risk factors for perforation of duodenal ulcer, highlighting any prevalent one in the occurrence of perforation in our region. Study design:-Descriptive/Retrospective study. 3[rd] surgical unit Nishter Hospital Multan. Subjects:-All the patients having DU perforation were included. 62 patients with DU perforation were evaluated with special emphasis on etiological risk factors. Findings were recorded in the proforma and results obtained were compared with national and international studies. Stress, Smoking, NSAIDs and H. Pylori are the important factors in the causation of duodenal ulcer perforation. In our series stress is involved in 80% of cases. Followed by smoking [69%], H. Pylon [64%] and NSAIDs [55%]. Stress, smoking; H-Pylon infection and NSAIDS abuse are the factors in southern Punjab which cause perforation of duodenal ulcer